A recent Practising Law Institute (PLI) program provided a timely overview of current issues with respect to the establishment of prime brokerage arrangements, including the negotiation of prime brokerage agreements; mergers and acquisitions of hedge fund managers; and the formation and operation of registered funds. This article summarizes the key points from that presentation. The speakers were Nora M. Jordan, a partner at Davis Polk & Wardwell LLP; Harry Jho, Principal of Harry Jho LLC; and Andrew Siegel, a partner and General Counsel of Perella Weinberg Partners.